There are serious drawbacks to upgrading this to an 5 or more wire thermostat system. The Comfort II system only needs 4 wires to the thermostat (Pwr, Gnd, Data, Clock) to operate. Since most installers chose the cheap prewire option and only used 4 or 5 wire to the thermostat. And since all the zones are controlled from this main thermostat, and the system is supplied temperature information from thermocouple devices in each zone which only required 2 wire bell cord. To upgrade, the whole system must be rewired. Or a Bluetooth or WiFi capable solution needs to be installed.
I tried upgrading 10 years ago after my system was damaged by lightning but wasn’t able to find anything that I could adapt to my 3 zone 2 story home. Since with all other options each zone requires a 5 or more wire thermostat system I was able to place one thermostat on a wall next to the air handler closet on the second floor, and a second thermostat in place of the old primary on the first floor using the existing 5 wire. Which was not optimal and I wound up switching back to the old system because of the loss of one zone and uneven cooling.
I have made a habit of picking up used controllers and thermostat boards to keep my system running for 23 years because lightning is a problem here.